|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Mazitschek, R, Huwe, A, Giannis, A|
|Journal||Org Biomol Chem|
|Date Published||2005 Jun 07|
|Keywords||Angiogenesis Inhibitors, Cyclohexanes, Fatty Acids, Unsaturated, Sesquiterpenes|
A promising approach among the numerous efforts to cure cancer is the interruption of the tumour-induced formation of new blood vessels (angiogenesis). By suppressing angiogenesis with drugs, the tumour can neither grow to a life threatening size, nor metastasize. The natural product fumagillin 1 and the structurally related ovalicin 2 are two of the most potent anti-angiogenic compounds. Here, we report the design and synthesis of novel fumagillin and ovalicin analogues lacking reactive epoxy functionalities, which were thought to be responsible for the severe toxic side-effects observed. We also report a new synthetic approach and the determination of the anti-angiogenic properties of these compounds in endothelial cells.
|Alternate Journal||Org. Biomol. Chem.|