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Nature DOI:10.1038/nature03723

Paths to understanding the genetic basis of autoimmune disease.

Publication TypeJournal Article
Year of Publication2005
AuthorsRioux, JD, Abbas, AK
JournalNature
Volume435
Issue7042
Pages584-9
Date Published2005 Jun 02
ISSN1476-4687
KeywordsAutoimmune Diseases, Clonal Anergy, Genetic Predisposition to Disease, Humans, Immune Tolerance, T-Lymphocytes
Abstract

Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances in genetic resources and tools are now making it possible to identify the sequence variants that contribute to autoimmune diseases--promising a better understanding of how we normally remain tolerant of our own tissue components, and how this goes wrong in autoimmune disease.

URLhttp://dx.doi.org/10.1038/nature03723
DOI10.1038/nature03723
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15931210?dopt=Abstract

Alternate JournalNature
PubMed ID15931210