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Journal of proteome research DOI:10.1021/pr0500962

Place of pattern in proteomic biomarker discovery.

Publication TypeJournal Article
Year of Publication2005
AuthorsGillette, MA, Mani, DR, Carr, SA
JournalJournal of proteome research
Volume4
Issue4
Pages1143-54
Date Published2005/1/1
ISSN1535-3893
Abstract

The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.

URLhttp://dx.doi.org/10.1021/pr0500962
DOI10.1021/pr0500962
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16083265?dopt=Abstract