You are here

J Proteome Res DOI:10.1021/pr0500962

Place of pattern in proteomic biomarker discovery.

Publication TypeJournal Article
Year of Publication2005
AuthorsGillette, MA, Mani, DR, Carr, SA
JournalJ Proteome Res
Volume4
Issue4
Pages1143-54
Date Published2005 Jul-Aug
ISSN1535-3893
KeywordsBiomarkers, Humans, Mass Spectrometry, Molecular Diagnostic Techniques, Neoplasms, Proteome, Reproducibility of Results
Abstract

The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.

URLhttp://dx.doi.org/10.1021/pr0500962
DOI10.1021/pr0500962
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16083265?dopt=Abstract

Alternate JournalJ. Proteome Res.
PubMed ID16083265