Scientific Publications

Place of pattern in proteomic biomarker discovery.

Publication TypeJournal Article
AuthorsGillette, MA, Mani D. R., and Carr SA
AbstractThe role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.
Year of Publication2005
JournalJournal of proteome research
Volume4
Issue4
Pages1143-54
Date Published (YYYY/MM/DD)2005/1/1
ISSN Number1535-3893
DOI10.1021/pr0500962
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/16083265?dopt=Abstract