DNA sequence and analysis of human chromosome 18.
Authors | |
Keywords | |
Abstract | Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements. |
Year of Publication | 2005
|
Journal | Nature
|
Volume | 437
|
Issue | 7058
|
Pages | 551-5
|
Date Published | 2005 Sep 22
|
ISSN | 1476-4687
|
URL | |
DOI | 10.1038/nature03983
|
PubMed ID | 16177791
|
Links |