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Org Lett DOI:10.1021/ol052269z

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Publication TypeJournal Article
Year of Publication2005
AuthorsUrgaonkar, S, La Pierre, HS, Meir, I, Lund, H, Raychaudhuri, D, Shaw, JT
JournalOrg Lett
Volume7
Issue25
Pages5609-12
Date Published2005 Dec 08
ISSN1523-7060
KeywordsAnti-Bacterial Agents, Bacterial Proteins, Biological Products, Chlorides, Cytokinesis, Cytoskeletal Proteins, Enzyme Inhibitors, Flavanones, GTP Phosphohydrolases, Stereoisomerism, Zinc Compounds
Abstract

[chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

URLhttp://dx.doi.org/10.1021/ol052269z
DOI10.1021/ol052269z
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16321003?dopt=Abstract

Alternate JournalOrg. Lett.
PubMed ID16321003
PubMed Central IDPMC2588422
Grant ListR03 AI062905 / AI / NIAID NIH HHS / United States
R03 AI062905-01 / AI / NIAID NIH HHS / United States
R03 AI062905-02 / AI / NIAID NIH HHS / United States
R01GM068025 / GM / NIGMS NIH HHS / United States