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Organic letters DOI:10.1021/ol0526165

Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums.

Publication TypeJournal Article
Year of Publication2006
AuthorsTaylor, AM, Schreiber, SL
JournalOrganic letters
Volume8
Issue1
Pages143-6
Date Published2006/01/05
ISSN1523-7060
Abstract

[reaction: see text] The asymmetric, catalytic addition of terminal alkynes to discrete alkyliminium species in the presence of copper bromide, QUINAP ligand, and triethylamine is reported. The reaction proceeds in high yield and high enantiomeric excess with a variety of substrates in solution and is also amenable to solid-phase synthesis.

URLhttp://dx.doi.org/10.1021/ol0526165
DOI10.1021/ol0526165
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16381588?dopt=Abstract