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Nature DOI:10.1038/nature04632

Human chromosome 11 DNA sequence and analysis including novel gene identification.

Publication TypeJournal Article
Year of Publication2006
AuthorsTaylor, TD, Noguchi, H, Totoki, Y, Toyoda, A, Kuroki, Y, Dewar, K, Lloyd, C, Itoh, T, Takeda, T, Kim, D-W, She, X, Barlow, KF, Bloom, T, Bruford, E, Chang, JL, Cuomo, CA, Eichler, E, FitzGerald, MG, Jaffe, DB, LaButti, K, Nicol, R, Park, H-S, Seaman, C, Sougnez, C, Yang, X, Zimmer, AR, Zody, MC, Birren, BW, Nusbaum, C, Fujiyama, A, Hattori, M, Rogers, J, Lander, ES, Sakaki, Y
Date Published2006 Mar 23
KeywordsChromosomes, Human, Pair 11, DNA, Gene Expression, Genes, Humans, Molecular Sequence Data, Physical Chromosome Mapping, Receptors, Odorant, Sequence Analysis, DNA

Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here--nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence--provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.


Alternate JournalNature
PubMed ID16554811
Grant ListG0000107 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom