You are here

Organic letters DOI:10.1021/ol0604724

Macrocycloadditions leading to conformationally restricted small molecules.

Publication TypeJournal Article
Year of Publication2006
AuthorsLooper, RE, Pizzirani, D, Schreiber, SL
JournalOrganic letters
Volume8
Issue10
Pages2063-6
Date Published2006/05/11
ISSN1523-7060
Abstract

[reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.

URLhttp://dx.doi.org/10.1021/ol0604724
DOI10.1021/ol0604724
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16671782?dopt=Abstract