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Clin Cancer Res DOI:10.1158/1078-0432.CCR-06-0414

Mouse models of lung cancer.

Publication TypeJournal Article
Year of Publication2006
AuthorsDutt, A, Wong, K-K
JournalClin Cancer Res
Volume12
Issue14 Pt 2
Pages4396s-4402s
Date Published2006 Jul 15
ISSN1078-0432
KeywordsAnimals, Disease Models, Animal, Lung Neoplasms, Mice, Mice, Knockout, Mice, Transgenic
Abstract

Human lung cancer is responsible for approximately 30% of all cancer deaths worldwide with >160,000 deaths in the United States alone annually. Recent advances in the identification of novel mutations relevant to lung cancer from a myriad of genomic studies might translate into meaningful diagnostic and therapeutic progress. Towards this end, a genetic model animal system that can validate the oncogenic roles of these mutations in vivo would facilitate the understanding of the pathogenesis of lung cancer as well as provide ideal preclinical models for targeted therapy testing. The mouse is a promising model system, as complex human genetic traits causal to lung cancer, from inherited polymorphisms to somatic mutations, can be recapitulated in its genome via genetic manipulation. We present here a brief overview of the existing mouse models of lung cancers and the challenges and opportunities for building the next generation of lung cancer mouse models.

URLhttp://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16857817
DOI10.1158/1078-0432.CCR-06-0414
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16857817?dopt=Abstract

Alternate JournalClin. Cancer Res.
PubMed ID16857817
Grant ListK08AG 2400401 / AG / NIA NIH HHS / United States