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Cell DOI:10.1016/j.cell.2006.09.007

Brain evolution and uniqueness in the human genome.

Publication TypeJournal Article
Year of Publication2006
AuthorsAmadio, JP, Walsh, CA
JournalCell
Volume126
Issue6
Pages1033-5
Date Published2006 Sep 22
ISSN0092-8674
KeywordsAnimals, Biological Evolution, Brain, Brain Chemistry, Conserved Sequence, Evolution, Molecular, Gene Expression Regulation, Developmental, Genome, Human, Humans, RNA, Untranslated
Abstract

Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in humans. As they report in a recent issue of Nature, their scan yielded a gene for a novel noncoding RNA that adopts a human-specific structure and may regulate neurodevelopment.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0092-8674(06)01154-8
DOI10.1016/j.cell.2006.09.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16990130?dopt=Abstract

Alternate JournalCell
PubMed ID16990130