|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Amadio, JP, Walsh, CA|
|Date Published||2006 Sep 22|
|Keywords||Animals, Biological Evolution, Brain, Brain Chemistry, Conserved Sequence, Evolution, Molecular, Gene Expression Regulation, Developmental, Genome, Human, Humans, RNA, Untranslated|
Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in humans. As they report in a recent issue of Nature, their scan yielded a gene for a novel noncoding RNA that adopts a human-specific structure and may regulate neurodevelopment.