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Curr Opin Genet Dev DOI:10.1016/j.gde.2006.09.001

Coevolution, modularity and human disease.

Publication TypeJournal Article
Year of Publication2006
AuthorsFraser, HB
JournalCurr Opin Genet Dev
Date Published2006 Dec
KeywordsAnimals, Evolution, Molecular, Genetic Diseases, Inborn, Genomics, Humans, Models, Genetic, Proteins, Saccharomyces cerevisiae

The concepts of coevolution and modularity have been studied separately for decades. Recent advances in genomics have led to the first systematic studies in each of these fields at the molecular level, resulting in several important discoveries. Both coevolution and modularity appear to be pervasive features of genomic data from all species studied to date, and their presence can be detected in many types of datasets, including genome sequences, gene expression data, and protein-protein interaction data. Moreover, the combination of these two ideas might have implications for our understanding of many aspects of biology, ranging from the general architecture of living systems to the causes of various human diseases.


Alternate JournalCurr. Opin. Genet. Dev.
PubMed ID17005391