|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Lamb, J, Crawford, ED, Peck, D, Modell, JW, Blat, IC, Wrobel, MJ, Lerner, J, Brunet, JP, Subramanian, A, Ross, KN, Reich, M, Hieronymus, H, Wei, G, Armstrong, SA, Haggarty, SJ, Clemons, PA, Wei, R, Carr, SA, Lander, ES, Golub, TR|
|Journal||Science (New York, N.Y.)|
|Keywords||Alzheimer Disease, Cancer, Cell Line, Databases, Dexamethasone, Drug Evaluation, Drug Resistance, Enzyme Inhibitors, Estrogens, Factual, Gene Expression, Gene Expression Profiling, Histone Deacetylases, HSP90 Heat-Shock Pr, Neoplasm, Preclinical, Tumor|
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.