Scientific Publications

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Publication TypeJournal Article
AuthorsLamb, J., Crawford ED, Peck D., Modell JW, Blat IC, Wrobel MJ, Lerner J., Brunet JP, Subramanian A., Ross KN, Reich M., Hieronymus H., Wei G., Armstrong SA, Haggarty SJ, Clemons PA, Wei R., Carr SA, Lander E. S., and Golub T. R.
AbstractTo pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.
Year of Publication2006
JournalScience (New York, N.Y.)
Date Published (YYYY/MM/DD)2006/09/29
ISSN Number0036-8075
KeywordsAlzheimer Disease, Cancer, Cell Line, Databases, Dexamethasone, Drug Evaluation, Drug Resistance, Enzyme Inhibitors, Estrogens, Factual, Gene Expression, Gene Expression Profiling, Histone Deacetylases, HSP90 Heat-Shock Pr, Neoplasm, Preclinical, Tumor