Scientific Publications

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.

Publication TypeJournal Article
AuthorsWei, G., Twomey D., Lamb J., Schlis K., Agarwal J., Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R., Golub T. R., and Armstrong SA
AbstractDrug resistance remains a major obstacle to successful cancer treatment. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression signature of glucocorticoid (GC) sensitivity/resistance in acute lymphoblastic leukemia (ALL) cells. The screen indicated that the mTOR inhibitor rapamycin profile matched the signature of GC sensitivity. We tested the hypothesis that rapamycin would induce GC sensitivity in lymphoid malignancy cells and found that it sensitized to GC-induced apoptosis via modulation of antiapoptotic MCL1. These data indicate that MCL1 is an important regulator of GC-induced apoptosis and that the combination of rapamycin and glucocorticoids has potential utility in lymphoid malignancies. Furthermore, this approach represents a strategy for identification of promising combination therapies for cancer.
Year of Publication2006
JournalCancer cell
Volume10
Issue4
Pages331-42
Date Published (YYYY/MM/DD)2006/10/01
ISSN Number1535-6108
DOI10.1016/j.ccr.2006.09.006
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17010674?dopt=Abstract