|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Duan, Z, Bradner, JE, Greenberg, E, LeVine, R, Foster, R, Mahoney, J, Seiden, MV|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
Signal transducer and activator of transcription 3 (Stat3) proteins have important roles in cancer cell survival and proliferation. Recent studies show that aberrant Stat3 activation promotes tumor growth and survival in several human cancers, and thus, presents an attractive pathway for the development of targeted anticancer therapy. Stat3 is a DNA-binding transcription factor, and thus, its function depends on cytoplasmic to nuclear translocation. To discover novel inhibitors of the Stat3 signaling pathway, we designed a cell-based screening assay capable of identifying compounds that inhibit Stat3 nuclear translocation and activity.