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Current opinion in chemical biology DOI:10.1016/j.cbpa.2006.11.031

A pipeline for ligand discovery using small-molecule microarrays.

Publication TypeJournal Article
Year of Publication2007
AuthorsDuffner, JL, Clemons, PA, Koehler, AN
JournalCurrent opinion in chemical biology
Volume11
Issue1
Pages74-82
Date Published2007/02/01
ISSN1367-5931
Abstract

Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1367-5931(06)00188-8
DOI10.1016/j.cbpa.2006.11.031
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17169601?dopt=Abstract