You are here

Curr Opin Chem Biol DOI:10.1016/j.cbpa.2006.11.031

A pipeline for ligand discovery using small-molecule microarrays.

Publication TypeJournal Article
Year of Publication2007
AuthorsDuffner, JL, Clemons, PA, Koehler, AN
JournalCurr Opin Chem Biol
Date Published2007 Feb
KeywordsBiological Products, Chemistry, Pharmaceutical, Combinatorial Chemistry Techniques, Ligands, Microarray Analysis, Molecular Probes, Peptides, Protein Processing, Post-Translational, Sensitivity and Specificity

Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs.


Alternate JournalCurr Opin Chem Biol
PubMed ID17169601
Grant ListN01-CO-12400 / CO / NCI NIH HHS / United States