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Gastroenterology DOI:10.1053/j.gastro.2006.10.032

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.

Publication TypeJournal Article
Year of Publication2007
AuthorsKim, SS, Peng, LF, Lin, W, Choe, WH, Sakamoto, N, Kato, N, Ikeda, M, Schreiber, SL, Chung, RT
JournalGastroenterology
Volume132
Issue1
Pages311-20
Date Published2007/01/01
ISSN0016-5085
Abstract

Only half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side effects. Thus, the identification of more effective and better tolerated agents is a high priority. We applied chemical biology to screen small molecules that regulate HCV.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0016-5085(06)02266-9
DOI10.1053/j.gastro.2006.10.032
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17241881?dopt=Abstract