Scientific Publications

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.

Publication TypeJournal Article
AuthorsKim, SS, Peng LF, Lin W., Choe WH, Sakamoto N., Kato N., Ikeda M., Schreiber SL, and Chung RT
AbstractOnly half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side effects. Thus, the identification of more effective and better tolerated agents is a high priority. We applied chemical biology to screen small molecules that regulate HCV.
Year of Publication2007
JournalGastroenterology
Volume132
Issue1
Pages311-20
Date Published (YYYY/MM/DD)2007/01/01
ISSN Number0016-5085
DOI10.1053/j.gastro.2006.10.032
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17241881?dopt=Abstract