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Annals of neurology DOI:10.1002/ana.21063

A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Publication TypeJournal Article
Year of Publication2007
AuthorsYeo, TW, De Jager, PL, Gregory, SG, Barcellos, LF, Walton, A, Goris, A, Fenoglio, C, Ban, M, Taylor, CJ, Goodman, RS, Walsh, E, Wolfish, CS, Horton, R, Traherne, J, Beck, S, Trowsdale, J, Caillier, SJ, Ivinson, AJ, Green, T, Pobywajlo, S, Lander, ES, Pericak-Vance, MA, Haines, JL, Daly, MJ, Oksenberg, JR, Hauser, SL, Compston, A, Hafler, DA, Rioux, JD, Sawcer, S
JournalAnnals of neurology
Volume61
Issue3
Pages228-36
Date Published2007/03/01
ISSN0364-5134
Abstract

Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed.

URLhttp://dx.doi.org/10.1002/ana.21063
DOI10.1002/ana.21063
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17252545?dopt=Abstract