Scientific Publications

A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Publication TypeJournal Article
AuthorsYeo, TW, De Jager PL, Gregory SG, Barcellos LF, Walton A., Goris A., Fenoglio C., Ban M., Taylor CJ, Goodman RS, Walsh E., Wolfish CS, Horton R., Traherne J., Beck S., Trowsdale J., Caillier SJ, Ivinson AJ, Green T., Pobywajlo S., Lander E. S., Pericak-Vance MA, Haines JL, Daly M. J., Oksenberg JR, Hauser SL, Compston A., Hafler DA, Rioux JD, and Sawcer S.
AbstractVariation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed.
Year of Publication2007
JournalAnnals of neurology
Volume61
Issue3
Pages228-36
Date Published (YYYY/MM/DD)2007/03/01
ISSN Number0364-5134
DOI10.1002/ana.21063
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17252545?dopt=Abstract