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Ann Neurol DOI:10.1002/ana.21063

A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Publication TypeJournal Article
Year of Publication2007
AuthorsYeo, TWai, De Jager, PL, Gregory, SG, Barcellos, LF, Walton, A, Goris, A, Fenoglio, C, Ban, M, Taylor, CJ, Goodman, RS, Walsh, E, Wolfish, CS, Horton, R, Traherne, J, Beck, S, Trowsdale, J, Caillier, SJ, Ivinson, AJ, Green, T, Pobywajlo, S, Lander, ES, Pericak-Vance, MA, Haines, JL, Daly, MJ, Oksenberg, JR, Hauser, SL, Compston, A, Hafler, DA, Rioux, JD, Sawcer, S
JournalAnn Neurol
Date Published2007 Mar
KeywordsAdult, Female, Genetic Predisposition to Disease, HLA-D Antigens, Humans, Major Histocompatibility Complex, Male, Microsatellite Repeats, Middle Aged, Multiple Sclerosis, Polymorphism, Single Nucleotide

OBJECTIVE: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed.

METHODS: Using a combination of microsatellite, single nucleotide polymorphism, and human leukocyte antigen (HLA) typing, we screened the MHC in trio families looking for evidence of residual association above and beyond that attributable to the established DRB1*1501 risk haplotype. We then refined this analysis by extending the genotyping of classical HLA loci into independent cases and control subjects.

RESULTS: Screening confirmed the presence of residual association and suggested that this was maximal in the region of the HLA-C gene. Extending analysis of the classical loci confirmed that this residual association is partly due to allelic heterogeneity at the HLA-DRB1 locus, but also reflects an independent effect from the HLA-C gene. Specifically, the HLA-C*05 allele, or a variant in tight linkage disequilibrium with it, appears to exert a protective effect (p = 3.3 x 10(-5)).

INTERPRETATION: Variation in the HLA-C gene influences susceptibility to multiple sclerosis independently of any effect attributable to the nearby HLA-DRB1 gene.


Alternate JournalAnn. Neurol.
PubMed ID17252545
PubMed Central IDPMC2737610
Grant List588 / / Multiple Sclerosis Society / United Kingdom
R01 NS049477 / NS / NINDS NIH HHS / United States
048880 / / Wellcome Trust / United Kingdom
057097 / / Wellcome Trust / United Kingdom
NS026799 / NS / NINDS NIH HHS / United States
NS032830 / NS / NINDS NIH HHS / United States
R01 NS032830 / NS / NINDS NIH HHS / United States
NS049477 / NS / NINDS NIH HHS / United States
K08 NS046341 / NS / NINDS NIH HHS / United States
R01 NS026799 / NS / NINDS NIH HHS / United States
K08 NS46341 / NS / NINDS NIH HHS / United States
G0401569 / / Medical Research Council / United Kingdom