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Science DOI:10.1126/science.1140693

The maternal-zygotic transition: death and birth of RNAs.

Publication TypeJournal Article
Year of Publication2007
AuthorsSchier, AF
JournalScience
Volume316
Issue5823
Pages406-7
Date Published2007 Apr 20
ISSN1095-9203
Keywords3' Untranslated Regions, Animals, Cell Cycle, Embryonic Development, Female, Gene Expression Regulation, Developmental, Gene Silencing, MicroRNAs, RNA Stability, RNA, Messenger, RNA, Messenger, Stored, RNA-Binding Proteins, Transcription, Genetic, Zygote
Abstract

Maternal gene products drive early development when the newly formed embryo is transcriptionally inactive. During the maternal-zygotic transition, embryonic transcription is initiated and many maternal RNAs are degraded. Multiple mechanisms regulate the birth of zygotic RNAs and the death of maternal RNAs. Genome activation appears to rely in part on the sequestration of transcriptional repressors by the exponentially increasing amount of DNA during cleavage divisions. Maternal RNA degradation is induced by the binding of proteins and microRNAs to the 3' untranslated region of target RNAs.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=17446392
DOI10.1126/science.1140693
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17446392?dopt=Abstract

Alternate JournalScience
PubMed ID17446392