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Curr Opin Genet Dev DOI:10.1016/j.gde.2007.04.010

Genetic determinants of QT interval variation and sudden cardiac death.

Publication TypeJournal Article
Year of Publication2007
AuthorsNewton-Cheh, C, Shah, R
JournalCurr Opin Genet Dev
Date Published2007 Jun
KeywordsAlleles, Arrhythmias, Cardiac, Death, Sudden, Cardiac, Genetic Predisposition to Disease, Genetic Variation, Humans, Time Factors

Electrocardiographic QT interval prolongation or shortening is a risk factor for sudden cardiac death. The study of Mendelian syndromes in families with extreme long and short QT interval duration and ventricular arrhythmias has led to the identification of genes encoding ion channel proteins important in myocardial repolarization. Rare mutations in such ion channel genes do not individually contribute substantially to the population burden of ventricular arrhythmias and sudden cardiac death. Only now are studies systematically testing the relationship between common variants in these genes--or elsewhere in the genome--and QT interval variation and sudden cardiac death. Identification of genetic variation underlying myocardial repolarization could have important implications for the prevention of both sporadic and drug-induced arrhythmias.


Alternate JournalCurr. Opin. Genet. Dev.
PubMed ID17467978
Grant ListHL080025 / HL / NHLBI NIH HHS / United States