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Nature chemical biology DOI:10.1038/nchembio.2007.15

Image-based chemical screening.

Publication TypeJournal Article
Year of Publication2007
AuthorsCarpenter, AE
JournalNature chemical biology
Volume3
Issue8
Pages461-5
Date Published2007/08/01
ISSN1552-4450
Abstract

Technological advances have made it feasible to conduct high-throughput small-molecule screens based on visual phenotypes of individual cells, using automated imaging and analysis. These screens are rapidly moving from being small, proof-of-principle tests to robust and widespread screens of hundreds of thousands of compounds. Automated imaging screens maximize the information obtained in an initial screen and improve the ability to select high-quality leads. In this Perspective, I highlight the key steps necessary for conducting a high-throughput image-based chemical compound screen.

URLhttp://dx.doi.org/10.1038/nchembio.2007.15
DOI10.1038/nchembio.2007.15
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17637778?dopt=Abstract