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Nat Chem Biol DOI:10.1038/nchembio.2007.15

Image-based chemical screening.

Publication TypeJournal Article
Year of Publication2007
AuthorsCarpenter, AE
JournalNat Chem Biol
Volume3
Issue8
Pages461-5
Date Published2007 Aug
ISSN1552-4450
KeywordsAnimals, Automation, Biological Assay, Chemistry, Pharmaceutical, Combinatorial Chemistry Techniques, Drug Design, Drug Evaluation, Preclinical, Equipment Design, Humans, Image Processing, Computer-Assisted, Kinetics, Models, Chemical, Phenotype, RNA Interference, Technology, Pharmaceutical
Abstract

Technological advances have made it feasible to conduct high-throughput small-molecule screens based on visual phenotypes of individual cells, using automated imaging and analysis. These screens are rapidly moving from being small, proof-of-principle tests to robust and widespread screens of hundreds of thousands of compounds. Automated imaging screens maximize the information obtained in an initial screen and improve the ability to select high-quality leads. In this Perspective, I highlight the key steps necessary for conducting a high-throughput image-based chemical compound screen.

URLhttp://dx.doi.org/10.1038/nchembio.2007.15
DOI10.1038/nchembio.2007.15
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17637778?dopt=Abstract

Alternate JournalNat. Chem. Biol.
PubMed ID17637778