|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Neafsey, DE, Galagan, JE|
|Journal||BMC evolutionary biology|
Natural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift. We looked for evidence of directional selection resulting in increased unpreferred codon usage (and presumably reduced translational efficiency) in three divergent clusters of eukaryotic genomes using a simple optimal-codon-based metric (Kp/Ku).