Scientific Publications

Positive selection for unpreferred codon usage in eukaryotic genomes.

Publication TypeJournal Article
AuthorsNeafsey, DE, and Galagan JE
AbstractNatural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift. We looked for evidence of directional selection resulting in increased unpreferred codon usage (and presumably reduced translational efficiency) in three divergent clusters of eukaryotic genomes using a simple optimal-codon-based metric (Kp/Ku).
Year of Publication2007
JournalBMC evolutionary biology
Volume7
Pages119
Date Published (YYYY/MM/DD)2007/07/18
DOI10.1186/1471-2148-7-119
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17640368?dopt=Abstract