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BMC evolutionary biology DOI:10.1186/1471-2148-7-119

Positive selection for unpreferred codon usage in eukaryotic genomes.

Publication TypeJournal Article
Year of Publication2007
AuthorsNeafsey, DE, Galagan, JE
JournalBMC evolutionary biology
Volume7
Pages119
Date Published2007/07/18
Abstract

Natural selection has traditionally been understood as a force responsible for pushing genes to states of higher translational efficiency, whereas lower translational efficiency has been explained by neutral mutation and genetic drift. We looked for evidence of directional selection resulting in increased unpreferred codon usage (and presumably reduced translational efficiency) in three divergent clusters of eukaryotic genomes using a simple optimal-codon-based metric (Kp/Ku).

URLhttp://www.biomedcentral.com/1471-2148/7/119
DOI10.1186/1471-2148-7-119
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17640368?dopt=Abstract