|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Peng, LF, Kim, SS, Matchacheep, S, Lei, X, Su, S, Lin, W, Runguphan, W, Choe, WH, Sakamoto, N, Ikeda, M, Kato, N, Beeler, AB, Porco JA, J, Schreiber, SL, Chung, RT|
|Journal||Antimicrobial agents and chemotherapy|
Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.