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Antimicrobial agents and chemotherapy DOI:10.1128/AAC.00233-07

Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Publication TypeJournal Article
Year of Publication2007
AuthorsPeng, LF, Kim, SS, Matchacheep, S, Lei, X, Su, S, Lin, W, Runguphan, W, Choe, WH, Sakamoto, N, Ikeda, M, Kato, N, Beeler, AB, Porco JA, J, Schreiber, SL, Chung, RT
JournalAntimicrobial agents and chemotherapy
Volume51
Issue10
Pages3756-9
Date Published2007/10/01
ISSN0066-4804
Abstract

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.

URLhttp://aac.asm.org/cgi/pmidlookup?view=long&pmid=17682098
DOI10.1128/AAC.00233-07
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17682098?dopt=Abstract