Scientific Publications

Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Publication TypeJournal Article
AuthorsPeng, LF, Kim SS, Matchacheep S., Lei X., Su S., Lin W., Runguphan W., Choe WH, Sakamoto N., Ikeda M., Kato N., Beeler AB, Porco JA Jr, Schreiber SL, and Chung RT
AbstractUsing our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.
Year of Publication2007
JournalAntimicrobial agents and chemotherapy
Volume51
Issue10
Pages3756-9
Date Published (YYYY/MM/DD)2007/10/01
ISSN Number0066-4804
DOI10.1128/AAC.00233-07
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/17682098?dopt=Abstract