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Organic letters DOI:10.1021/ol701911u

Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.

Publication TypeJournal Article
Year of Publication2007
AuthorsWei, J, Shaw, JT
JournalOrganic letters
Volume9
Issue20
Pages4077-80
Date Published2007/09/27
ISSN1523-7060
Abstract

A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.

URLhttp://dx.doi.org/10.1021/ol701911u
DOI10.1021/ol701911u
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17760458?dopt=Abstract