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Science DOI:10.1126/science.1143708

The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.

Publication TypeJournal Article
Year of Publication2007
AuthorsCuomo, CA, Güldener, U, Xu, J-R, Trail, F, B Turgeon, G, Di Pietro, A, Walton, JD, Ma, L-J, Baker, SE, Rep, M, Adam, G, Antoniw, J, Baldwin, T, Calvo, S, Chang, Y-L, DeCaprio, D, Gale, LR, Gnerre, S, Goswami, RS, Hammond-Kosack, K, Harris, LJ, Hilburn, K, Kennell, JC, Kroken, S, Magnuson, JK, Mannhaupt, G, Mauceli, E, Mewes, H-W, Mitterbauer, R, Muehlbauer, G, Münsterkötter, M, Nelson, D, O'donnell, K, Ouellet, T, Qi, W, Quesneville, H, M Roncero, IG, Seong, K-Y, Tetko, IV, Urban, M, Waalwijk, C, Ward, TJ, Yao, J, Birren, BW, H Kistler, C
Date Published2007 Sep 07
KeywordsDNA, Fungal, Evolution, Molecular, Fusarium, Genome, Fungal, Hordeum, Molecular Sequence Data, Plant Diseases, Point Mutation, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Sequence Analysis, DNA

We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.


Alternate JournalScience
PubMed ID17823352
Grant ListU54 HG003067 / HG / NHGRI NIH HHS / United States