|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Cuomo, CA, Güldener, U, Xu, JR, Trail, F, Turgeon, BG, Di Pietro, A, Walton, JD, Ma, LJ, Baker, SE, Rep, M, Adam, G, Antoniw, J, Baldwin, T, Calvo, S, Chang, YL, DeCaprio, D, Gale, LR, Gnerre, S, Goswami, RS, Hammond-Kosack, K, Harris, LJ, Hilburn, K, Kennell, JC, Kroken, S, Magnuson, JK, Mannhaupt, G, Mauceli, E, Mewes, HW, Mitterbauer, R, Muehlbauer, G, Münsterkötter, M, Nelson, D, O'donnell, K, Ouellet, T, Qi, W, Quesneville, H, Roncero, MI, Seong, KY, Tetko, IV, Urban, M, Waalwijk, C, Ward, TJ, Yao, J, Birren, BW, Kistler, HC|
|Journal||Science (New York, N.Y.)|
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.