|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Cuomo, CA, Güldener, U, Xu, J-R, Trail, F, B Turgeon, G, Di Pietro, A, Walton, JD, Ma, L-J, Baker, SE, Rep, M, Adam, G, Antoniw, J, Baldwin, T, Calvo, S, Chang, Y-L, DeCaprio, D, Gale, LR, Gnerre, S, Goswami, RS, Hammond-Kosack, K, Harris, LJ, Hilburn, K, Kennell, JC, Kroken, S, Magnuson, JK, Mannhaupt, G, Mauceli, E, Mewes, H-W, Mitterbauer, R, Muehlbauer, G, Münsterkötter, M, Nelson, D, O'donnell, K, Ouellet, T, Qi, W, Quesneville, H, M Roncero, IG, Seong, K-Y, Tetko, IV, Urban, M, Waalwijk, C, Ward, TJ, Yao, J, Birren, BW, H Kistler, C|
|Date Published||2007 Sep 07|
|Keywords||DNA, Fungal, Evolution, Molecular, Fusarium, Genome, Fungal, Hordeum, Molecular Sequence Data, Plant Diseases, Point Mutation, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Sequence Analysis, DNA|
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
|Grant List||U54 HG003067 / HG / NHGRI NIH HHS / United States|