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Science (New York, N.Y.) DOI:10.1126/science.1138764

Comment on "The consensus coding sequences of human breast and colorectal cancers".

Publication TypeJournal Article
Year of Publication2007
AuthorsGetz, G, Höfling, H, Mesirov, JP, Golub, TR, Meyerson, M, Tibshirani, R, Lander, ES
JournalScience (New York, N.Y.)
Volume317
Issue5844
Pages1500
Date Published2007/09/14
ISSN0036-8075
Abstract

Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported nearly 200 novel cancer genes said to have a 90% probability of being involved in colon or breast cancer. However, their analysis raises two statistical concerns. When these concerns are addressed, few genes with significantly elevated mutation rates remain. Although the biological methodology in Sjöblom et al. is sound, more samples are needed to achieve sufficient power.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=17872428
DOI10.1126/science.1138764
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17872428?dopt=Abstract