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Science DOI:10.1126/science.1138764

Comment on "The consensus coding sequences of human breast and colorectal cancers".

Publication TypeJournal Article
Year of Publication2007
AuthorsGetz, G, Höfling, H, Mesirov, JP, Golub, TR, Meyerson, M, Tibshirani, R, Lander, ES
JournalScience
Volume317
Issue5844
Pages1500
Date Published2007 Sep 14
ISSN1095-9203
KeywordsBreast Neoplasms, Colorectal Neoplasms, Consensus Sequence, Female, Genes, Neoplasm, Genome, Human, Humans, Male, Mutation, Probability
Abstract

Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported nearly 200 novel cancer genes said to have a 90% probability of being involved in colon or breast cancer. However, their analysis raises two statistical concerns. When these concerns are addressed, few genes with significantly elevated mutation rates remain. Although the biological methodology in Sjöblom et al. is sound, more samples are needed to achieve sufficient power.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=17872428
DOI10.1126/science.1138764
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17872428?dopt=Abstract

Alternate JournalScience
PubMed ID17872428