You are here

Nat Genet DOI:10.1038/ng.2007.10

Efficient mapping of mendelian traits in dogs through genome-wide association.

Publication TypeJournal Article
Year of Publication2007
AuthorsKarlsson, EK, Baranowska, I, Wade, CM, Hillbertz, NHCSalmon, Zody, MC, Anderson, N, Biagi, TM, Patterson, N, Pielberg, GRosengren, Kulbokas, EJ, Comstock, KE, Keller, ET, Mesirov, JP, von Euler, H, Kämpe, O, Hedhammar, Å, Lander, ES, Andersson, G, Andersson, L, Lindblad-Toh, K
JournalNat Genet
Volume39
Issue11
Pages1321-8
Date Published2007 Nov
ISSN1546-1718
KeywordsAnimals, Breeding, Chromosome Mapping, Dogs, Female, Genetic Linkage, Genome, Hair Color, Haplotypes, Male, Melanocytes, Microphthalmia-Associated Transcription Factor, Mutation, Polymorphism, Single Nucleotide, Promoter Regions, Genetic
Abstract

With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with approximately 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only approximately 20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting (S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of

URLhttp://dx.doi.org/10.1038/ng.2007.10
DOI10.1038/ng.2007.10
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17906626?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID17906626