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N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.
|Publication Type||Journal Article|
|Authors||Mukherjee, S., Robinson CA, Howe AG, Mazor T., Wood PA, Urgaonkar S., Hebert AM, Raychaudhuri D., and Shaw JT|
|Abstract||A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20+/-5% at 100microM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.|
|Year of Publication||2007|
|Journal||Bioorganic & medicinal chemistry letters|
|Date Published (YYYY/MM/DD)||2007/12/01|