|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Mukherjee, S, Robinson, CA, Howe, AG, Mazor, T, Wood, PA, Urgaonkar, S, Hebert, AM, Raychaudhuri, D, Shaw, JT|
|Journal||Bioorganic & medicinal chemistry letters|
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20+/-5% at 100microM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.