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Nat Genet DOI:10.1038/ng.2007.27

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Publication TypeJournal Article
Year of Publication2007
AuthorsPlenge, RM, Cotsapas, C, Davies, L, Price, AL, de Bakker, PIW, Maller, J, Pe'er, I, Burtt, NP, Blumenstiel, B, DeFelice, M, Parkin, M, Barry, R, Winslow, W, Healy, C, Graham, RR, Neale, BM, Izmailova, E, Roubenoff, R, Parker, AN, Glass, R, Karlson, EW, Maher, N, Hafler, DA, Lee, DM, Seldin, MF, Remmers, EF, Lee, AT, Padyukov, L, Alfredsson, L, Coblyn, J, Weinblatt, ME, Gabriel, SB, Purcell, S, Klareskog, L, Gregersen, PK, Shadick, NA, Daly, MJ, Altshuler, D
JournalNat Genet
Volume39
Issue12
Pages1477-82
Date Published2007 Dec
ISSN1546-1718
KeywordsAlleles, Arthritis, Rheumatoid, Case-Control Studies, Chromosomes, Human, Pair 6, Female, Genetic Predisposition to Disease, Genome, Human, Humans, Male, Polymorphism, Single Nucleotide
Abstract

To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in comparison to publicly available genotype data for 1,211 related individuals from the Framingham Heart Study. After evaluating and adjusting for technical and population biases, we identified a SNP at 6q23 (rs10499194, approximately 150 kb from TNFAIP3 and OLIG3) that was reproducibly associated with rheumatoid arthritis both in the genome-wide association (GWA) scan and in 5,541 additional case-control samples (P = 10(-3), GWA scan; P

URLhttp://dx.doi.org/10.1038/ng.2007.27
DOI10.1038/ng.2007.27
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17982456?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID17982456
PubMed Central IDPMC2652744
Grant ListR01-AR44422 / AR / NIAMS NIH HHS / United States
K08 AI055314-03 / AI / NIAID NIH HHS / United States
R01 AR044422 / AR / NIAMS NIH HHS / United States
K08 AI055314-02 / AI / NIAID NIH HHS / United States
K08 AI055314-01A1 / AI / NIAID NIH HHS / United States
K08 AI055314-05 / AI / NIAID NIH HHS / United States
N01-AR-2-2263 / AR / NIAMS NIH HHS / United States
AI55314-3 / AI / NIAID NIH HHS / United States
K08 AI055314 / AI / NIAID NIH HHS / United States
K08 AI055314-04 / AI / NIAID NIH HHS / United States