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Gene expression-based screening for inhibitors of PDGFR signaling.
| Publication Type | Journal Article |
| Authors | Antipova, AA, Stockwell BR, and Golub T. R. |
| Abstract | Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest. |
| Year of Publication | 2012 |
| Journal | Genome biology |
| Volume | 9 |
| Issue | 3 |
| Pages | R47 |
| Date Published (YYYY/MM/DD) | 2012/01/05 |
| ISSN Number | 1465-6906 |
| DOI | 10.1186/gb-2008-9-3-r47 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/18312689?dopt=Abstract |
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