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Theor Popul Biol DOI:10.1016/j.tpb.2008.01.001

Can one learn history from the allelic spectrum?

Publication TypeJournal Article
Year of Publication2008
AuthorsMyers, S, Fefferman, C, Patterson, N
JournalTheor Popul Biol
Volume73
Issue3
Pages342-8
Date Published2008 May
ISSN1096-0325
KeywordsAlleles, Gene Frequency, Genetics, Population, Humans, Models, Theoretical, Population Density
Abstract

It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0040-5809(08)00003-8
DOI10.1016/j.tpb.2008.01.001
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18321552?dopt=Abstract

Alternate JournalTheor Popul Biol
PubMed ID18321552