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J Org Chem DOI:10.1021/jo702557d

Zinc-catalyzed silylation of terminal alkynes.

Publication TypeJournal Article
Year of Publication2008
AuthorsRahaim, RJ, Shaw, JT
JournalJ Org Chem
Volume73
Issue7
Pages2912-5
Date Published2008 Apr 04
ISSN0022-3263
KeywordsAlkynes, Catalysis, Molecular Structure, Organometallic Compounds, Organosilicon Compounds, Stereoisomerism, Zinc
Abstract

A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and catalytic quantities of Zn(OTf)2 has been developed. The reaction works well for a variety of substrates including reactive esters. Fifteen examples with yields of >90% are reported.

URLhttp://dx.doi.org/10.1021/jo702557d
DOI10.1021/jo702557d
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18331056?dopt=Abstract

Alternate JournalJ. Org. Chem.
PubMed ID18331056