Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

PLoS Genet
Authors
Keywords
Abstract

Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ancestry genomes. We performed large scale meta-analyses and replications in up to 52,895 individuals for BMI and up to 23,095 individuals for WHRadjBMI from the African Ancestry Anthropometry Genetics Consortium (AAAGC) using 1000 Genomes phase 1 imputed GWAS to improve coverage of both common and low frequency variants in the low linkage disequilibrium African ancestry genomes. In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P

Year of Publication
2017
Journal
PLoS Genet
Volume
13
Issue
4
Pages
e1006719
Date Published
2017 Apr
ISSN
1553-7404
DOI
10.1371/journal.pgen.1006719
PubMed ID
28430825
PubMed Central ID
PMC5419579
Links
Grant list
U01 HG007417 / HG / NHGRI NIH HHS / United States
K99 HL130580 / HL / NHLBI NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
U10 CA037429 / CA / NCI NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
R01 DK113003 / DK / NIDDK NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
U01 CA127298 / CA / NCI NIH HHS / United States
UG1 CA189974 / CA / NCI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
R01 HD056465 / HD / NICHD NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
R01 CA088164 / CA / NCI NIH HHS / United States
UM1 CA182883 / CA / NCI NIH HHS / United States