Scientific Publications

Application of natural product-inspired diversity-oriented synthesis to drug discovery.

Publication TypeJournal Article
AuthorsMarcaurelle, LA, and Johannes CW
AbstractNatural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.
Year of Publication2012
JournalProgress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
Volume66
Pages187, 189-216
Date Published (YYYY/MM/DD)2012/01/05
ISSN Number0071-786X
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18416306?dopt=Abstract