Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet.

Am J Clin Nutr
Authors
Keywords
Abstract

Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD). We evaluated the associations between ) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); ) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and ) 1-y changes in lipid species and subsequent CVD. With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]. Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles (-trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant (

Year of Publication
2017
Journal
Am J Clin Nutr
Volume
106
Issue
4
Pages
973-983
Date Published
2017 Oct
ISSN
1938-3207
DOI
10.3945/ajcn.116.151159
PubMed ID
28814398
PubMed Central ID
PMC5611779
Links
Grant list
R01 HL118264 / HL / NHLBI NIH HHS / United States