You are here

Journal of the National Cancer Institute DOI:10.1093/jnci/djn150

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.

Publication TypeJournal Article
Year of Publication2008
AuthorsSetlur, SR, Mertz, KD, Hoshida, Y, Demichelis, F, Lupien, M, Perner, S, Sboner, A, Pawitan, Y, Andrén, O, Johnson, LA, Tang, J, Adami, HO, Calza, S, Chinnaiyan, AM, Rhodes, D, Tomlins, S, Fall, K, Mucci, LA, Kantoff, PW, Stampfer, MJ, Andersson, SO, Varenhorst, E, Johansson, JE, Brown, M, Golub, TR, Rubin, MA
JournalJournal of the National Cancer Institute
Volume100
Issue11
Pages815-25
Date Published2008/06/04
ISSN0027-8874
Abstract

The majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation-specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate cancer defined by this fusion.

URLhttp://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18505969
DOI10.1093/jnci/djn150
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18505969?dopt=Abstract