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The New England journal of medicine DOI:10.1056/NEJMoa0804525

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

Publication TypeJournal Article
Year of Publication2008
AuthorsHoshida, Y, Villanueva, A, Kobayashi, M, Peix, J, Chiang, DY, Camargo, A, Gupta, S, Moore, J, Wrobel, MJ, Lerner, J, Reich, M, Chan, JA, Glickman, JN, Ikeda, K, Hashimoto, M, Watanabe, G, Daidone, MG, Roayaie, S, Schwartz, M, Thung, S, Salvesen, HB, Gabriel, S, Mazzaferro, V, Bruix, J, Friedman, SL, Kumada, H, Llovet, JM, Golub, TR
JournalThe New England journal of medicine
Date Published2008/11/06

It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissue.