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Malaria journal DOI:10.1186/1475-2875-7-223

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking.

Publication TypeJournal Article
Year of Publication2008
AuthorsDaniels, R, Volkman, SK, Milner, DA, Mahesh, N, Neafsey, DE, Park, DJ, Rosen, D, Angelino, E, Sabeti, PC, Wirth, DF, Wiegand, RC
JournalMalaria journal
Date Published2008/10/29

Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such an assay could be used to distinguish recrudescence from re-infection in drug trials, to monitor the frequency and distribution of specific parasites in a patient population undergoing drug treatment or vaccine challenge, or for tracking samples and determining purity of isolates in the laboratory during culture adaptation and sub-cloning, as well as routine passage.