Genetic mapping in human disease.
Science
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Abstract | Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead. |
Year of Publication | 2008
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Journal | Science
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Volume | 322
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Issue | 5903
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Pages | 881-8
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Date Published | 2008 Nov 07
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ISSN | 1095-9203
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URL | |
DOI | 10.1126/science.1156409
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PubMed ID | 18988837
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PubMed Central ID | PMC2694957
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Grant list | U54 HG003067 / HG / NHGRI NIH HHS / United States
U54 HG003067-03 / HG / NHGRI NIH HHS / United States
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