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Science DOI:10.1126/science.1156409

Genetic mapping in human disease.

Publication TypeJournal Article
Year of Publication2008
AuthorsAltshuler, D, Daly, MJ, Lander, ES
JournalScience
Volume322
Issue5903
Pages881-8
Date Published2008 Nov 07
ISSN1095-9203
KeywordsChromosome Mapping, Cloning, Molecular, Disease, Genetic Linkage, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Linkage Disequilibrium, Mutation, Physical Chromosome Mapping, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Risk Factors, Selection, Genetic
Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=18988837
DOI10.1126/science.1156409
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18988837?dopt=Abstract

Alternate JournalScience
PubMed ID18988837
PubMed Central IDPMC2694957
Grant ListU54 HG003067 / HG / NHGRI NIH HHS / United States
U54 HG003067-03 / HG / NHGRI NIH HHS / United States