You are here

Science (New York, N.Y.) DOI:10.1126/science.1156409

Genetic mapping in human disease.

Publication TypeJournal Article
Year of Publication2008
AuthorsAltshuler, D, Daly, MJ, Lander, ES
JournalScience (New York, N.Y.)
Volume322
Issue5903
Pages881-8
Date Published2008/11/07
ISSN0036-8075
Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=18988837
DOI10.1126/science.1156409
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18988837?dopt=Abstract