Genetic mapping in human disease.

Science
Authors
Keywords
Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

Year of Publication
2008
Journal
Science
Volume
322
Issue
5903
Pages
881-8
Date Published
2008 Nov 07
ISSN
1095-9203
URL
DOI
10.1126/science.1156409
PubMed ID
18988837
PubMed Central ID
PMC2694957
Links
Grant list
U54 HG003067 / HG / NHGRI NIH HHS / United States
U54 HG003067-03 / HG / NHGRI NIH HHS / United States