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Genome biology DOI:10.1186/gb-2008-9-12-r171

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Publication TypeJournal Article
Year of Publication2008
AuthorsNeafsey, DE, Schaffner, SF, Volkman, SK, Park, D, Montgomery, P, Milner DA, J, Lukens, A, Rosen, D, Daniels, R, Houde, N, Cortese, JF, Tyndall, E, Gates, C, Stange-Thomann, N, Sarr, O, Ndiaye, D, Ndir, O, Mboup, S, Ferreira, MU, Moraes Sdo, L, Dash, AP, Chitnis, CE, Wiegand, RC, Hartl, DL, Birren, BW, Lander, ES, Sabeti, PC, Wirth, DF
JournalGenome biology
Date Published2008/01/01

The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity in P. falciparum have begun to elucidate the demographic history of the species, as well as patterns of population structure and patterns of linkage disequilibrium within its genome. Such studies will be greatly enhanced by new genomic tools and recent large-scale efforts to map genomic variation. To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum.