Scientific Publications

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Publication TypeJournal Article
AuthorsNeafsey, DE, Schaffner SF, Volkman SK, Park D., Montgomery P., Milner DA Jr, Lukens A., Rosen D., Daniels R., Houde N., Cortese JF, Tyndall E., Gates C., Stange-Thomann N., Sarr O., Ndiaye D., Ndir O., Mboup S., Ferreira MU, Moraes Sdo L., Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander E. S., Sabeti PC, and Wirth DF
AbstractThe malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity in P. falciparum have begun to elucidate the demographic history of the species, as well as patterns of population structure and patterns of linkage disequilibrium within its genome. Such studies will be greatly enhanced by new genomic tools and recent large-scale efforts to map genomic variation. To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum.
Year of Publication2012
JournalGenome biology
Volume9
Issue12
PagesR171
Date Published (YYYY/MM/DD)2012/01/07
ISSN Number1465-6906
DOI10.1186/gb-2008-9-12-r171
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19077304?dopt=Abstract