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Nature genetics DOI:10.1038/ng.200

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Publication TypeJournal Article
Year of Publication2008
AuthorsGraham, RR, Cotsapas, C, Davies, L, Hackett, R, Lessard, CJ, Leon, JM, Burtt, NP, Guiducci, C, Parkin, M, Gates, C, Plenge, RM, Behrens, TW, Wither, JE, Rioux, JD, Fortin, PR, Graham, DC, Wong, AK, Vyse, TJ, Daly, MJ, Altshuler, D, Moser, KL, Gaffney, PM
JournalNature genetics
Volume40
Issue9
Pages1059-61
Date Published2008/09/01
ISSN1061-4036
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

URLhttp://dx.doi.org/10.1038/ng.200
DOI10.1038/ng.200
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19165918?dopt=Abstract