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Nat Genet DOI:10.1038/ng.200

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Publication TypeJournal Article
Year of Publication2008
AuthorsGraham, RR, Cotsapas, C, Davies, L, Hackett, R, Lessard, CJ, Leon, JM, Burtt, NP, Guiducci, C, Parkin, M, Gates, C, Plenge, RM, Behrens, TW, Wither, JE, Rioux, JD, Fortin, PR, Graham, DCunningham, Wong, AK, Vyse, TJ, Daly, MJ, Altshuler, D, Moser, KL, Gaffney, PM
JournalNat Genet
Volume40
Issue9
Pages1059-61
Date Published2008 Sep
ISSN1061-4036
KeywordsArthritis, Rheumatoid, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Intracellular Signaling Peptides and Proteins, Lupus Erythematosus, Systemic, Nuclear Proteins, Polymorphism, Single Nucleotide, Tumor Necrosis Factor alpha-Induced Protein 3
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

URLhttp://dx.doi.org/10.1038/ng.200
DOI10.1038/ng.200
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19165918?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID19165918
PubMed Central IDPMC2772171
Grant ListR01 MH061675 / MH / NIMH NIH HHS / United States
MH061675 / MH / NIMH NIH HHS / United States
R01 AI063274 / AI / NIAID NIH HHS / United States
F32 AR050927 / AR / NIAMS NIH HHS / United States
MH 63420 / MH / NIMH NIH HHS / United States
MH60870 / MH / NIMH NIH HHS / United States
MH59586 / MH / NIMH NIH HHS / United States
R01 AR043274-12 / AR / NIAMS NIH HHS / United States
R56 AI063274 / AI / NIAID NIH HHS / United States
P30 AR053483 / AR / NIAMS NIH HHS / United States
MH067257 / MH / NIMH NIH HHS / United States
AR043247 / AR / NIAMS NIH HHS / United States
AR052125 / AR / NIAMS NIH HHS / United States
K08 AR002105 / AR / NIAMS NIH HHS / United States
5F32AR50927 / AR / NIAMS NIH HHS / United States
076113 / / Wellcome Trust / United Kingdom
R01 AR052125 / AR / NIAMS NIH HHS / United States
AI063274 / AI / NIAID NIH HHS / United States
R01 MH067257 / MH / NIMH NIH HHS / United States
R01 MH060870 / MH / NIMH NIH HHS / United States
R01 MH059571 / MH / NIMH NIH HHS / United States
R01 MH059565 / MH / NIMH NIH HHS / United States
R01 MH059587 / MH / NIMH NIH HHS / United States
K08 AR002105-03 / AR / NIAMS NIH HHS / United States
MH060879 / MH / NIMH NIH HHS / United States
MH059565 / MH / NIMH NIH HHS / United States
R01 MH059586 / MH / NIMH NIH HHS / United States
MH059588 / MH / NIMH NIH HHS / United States
R01 MH059566 / MH / NIMH NIH HHS / United States
R01 MH063420 / MH / NIMH NIH HHS / United States
R01 MH059588 / MH / NIMH NIH HHS / United States
MH59566 / MH / NIMH NIH HHS / United States
K08 AR002105-02 / AR / NIAMS NIH HHS / United States
R01 AR056768 / AR / NIAMS NIH HHS / United States
R01 AR052125-03 / AR / NIAMS NIH HHS / United States
R01 AR043274 / AR / NIAMS NIH HHS / United States
R01 MH060879 / MH / NIMH NIH HHS / United States
F32 AR050927-02 / AR / NIAMS NIH HHS / United States
MH59587 / MH / NIMH NIH HHS / United States