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Sci Rep DOI:10.1038/s41598-018-30783-1

Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort.

Publication TypeJournal Article
Year of Publication2018
AuthorsGurry, T, Gibbons, SM, Nguyen, LThanh Tu, Kearney, SM, Ananthakrishnan, A, Jiang, X, Duvallet, C, Kassam, Z, Alm, EJ
Corporate AuthorsHST Microbiome Consortium*
JournalSci Rep
Date Published2018 Aug 23

Dietary interventions to manipulate the human gut microbiome for improved health have received increasing attention. However, their design has been limited by a lack of understanding of the quantitative impact of diet on a host's microbiota. We present a highly controlled diet perturbation experiment in a healthy, human cohort in which individual micronutrients are spiked in against a standardized background. We identify strong and predictable responses of specific microbes across participants consuming prebiotic spike-ins, at the level of both strains and functional genes, suggesting fine-scale resource partitioning in the human gut. No predictable responses to non-prebiotic micronutrients were found. Surprisingly, we did not observe decreases in day-to-day variability of the microbiota compared to a complex, varying diet, and instead found evidence of diet-induced stress and an associated loss of biodiversity. Our data offer insights into the effect of a low complexity diet on the gut microbiome, and suggest that effective personalized dietary interventions will rely on functional, strain-level characterization of a patient's microbiota.


Alternate JournalSci Rep
PubMed ID30139999