|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Burke, KE, Ananthakrishnan, AN, Lochhead, P, Liu, SPo-Hong, Olen, O, Ludvigsson, JF, Richter, JM, Tworoger, SS, Chan, AT, Khalili, H|
|Date Published||2018 Aug 22|
BACKGROUND AND AIMS: Microscopic colitis is a chronic inflammatory disorder of the colon primarily affecting postmenopausal women. However, the relationship between hormonal determinants, including reproductive and menopausal factors, and risk of microscopic colitis has yet to be characterized.
METHODS: We collected data from 227,766 women who participated in the Nurses' Health Study (NHS) and NHSII without a baseline history of microscopic colitis. Reproductive and menopausal factors were assessed in 1988 in the NHS and 1989 in the NHSII, and updated biennially. Cases of microscopic colitis were confirmed through review of pathology records. We used Cox proportional hazards modeling to estimate hazard ratios (HRs) and 95% CIs.
RESULTS: Through 2014 in NHS and 2015 in NHSII, we confirmed 275 incident cases of microscopic colitis over 5,147,282 person-years. Compared to never-use, current use of menopausal hormone therapy was associated with increased risk of microscopic colitis (multivariable-adjusted HR = 2.64; 95% CI 1.78 - 3.90). The risk increased with longer duration of use (P
CONCLUSIONS: In 2 large prospective cohort studies, we observed an association between exogenous hormone use and incident microscopic colitis. Further studies are needed to determine the mechanisms underlying these associations.