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Journal of the American Chemical Society DOI:10.1021/ja807772w

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.

Publication TypeJournal Article
Year of Publication2009
AuthorsBowers, AA, Greshock, TJ, West, N, Estiu, G, Schreiber, SL, Wiest, O, Williams, RM, Bradner, JE
JournalJournal of the American Chemical Society
Volume131
Issue8
Pages2900-5
Date Published2009/03/04
ISSN0002-7863
Abstract

The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.

URLhttp://dx.doi.org/10.1021/ja807772w
DOI10.1021/ja807772w
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19193120?dopt=Abstract