Scientific Publications

Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.

Publication TypeJournal Article
AuthorsNilsson, B., Johansson M., Al-Shahrour F., Carpenter AE, and Ebert BL
AbstractMOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
Year of Publication2009
JournalBioinformatics (Oxford, England)
Volume25
Issue8
Pages1078-9
Date Published (YYYY/MM/DD)2009/04/15
ISSN Number1367-4803
DOI10.1093/bioinformatics/btp091
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19228802?dopt=Abstract