Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.

Bioinformatics
Authors
Keywords
Abstract

MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.

RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.

Year of Publication
2009
Journal
Bioinformatics
Volume
25
Issue
8
Pages
1078-9
Date Published
2009 Apr 15
ISSN
1367-4811
URL
DOI
10.1093/bioinformatics/btp091
PubMed ID
19228802
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