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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/btp091

Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.

Publication TypeJournal Article
Year of Publication2009
AuthorsNilsson, B, Johansson, M, Al-Shahrour, F, Carpenter, AE, Ebert, BL
JournalBioinformatics (Oxford, England)
Volume25
Issue8
Pages1078-9
Date Published2009/04/15
ISSN1367-4803
Abstract

MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=19228802
DOI10.1093/bioinformatics/btp091
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19228802?dopt=Abstract