|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Nilsson, B, Johansson, M, Al-Shahrour, F, Carpenter, AE, Ebert, BL|
|Date Published||2009 Apr 15|
|Keywords||Algorithms, Chromosome Aberrations, Computational Biology, Gene Dosage, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide|
MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.
RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.