Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
Bioinformatics
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Abstract | MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy. |
Year of Publication | 2009
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Journal | Bioinformatics
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Volume | 25
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Issue | 8
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Pages | 1078-9
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Date Published | 2009 Apr 15
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ISSN | 1367-4811
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URL | |
DOI | 10.1093/bioinformatics/btp091
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PubMed ID | 19228802
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