|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Bowers, AA, West, N, Newkirk, TL, Troutman-Youngman, AE, Schreiber, SL, Wiest, O, Bradner, JE, Williams, RM|
Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access six variants of the side-chain zinc-binding domain, while adaptation of our previously reported modular synthesis allowed probing of the macrocyclic cap group.