You are here

Organic letters DOI:10.1021/ol900078k

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.

Publication TypeJournal Article
Year of Publication2009
AuthorsBowers, AA, West, N, Newkirk, TL, Troutman-Youngman, AE, Schreiber, SL, Wiest, O, Bradner, JE, Williams, RM
JournalOrganic letters
Volume11
Issue6
Pages1301-4
Date Published2009/03/19
ISSN1523-7060
Abstract

Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access six variants of the side-chain zinc-binding domain, while adaptation of our previously reported modular synthesis allowed probing of the macrocyclic cap group.

URLhttp://dx.doi.org/10.1021/ol900078k
DOI10.1021/ol900078k
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19239241?dopt=Abstract