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Organic letters DOI:10.1021/ol900173t

Skeletally diverse small molecules using a build/couple/pair strategy.

Publication TypeJournal Article
Year of Publication2009
AuthorsUchida, T, Rodriquez, M, Schreiber, SL
JournalOrganic letters
Volume11
Issue7
Pages1559-62
Date Published2009/04/02
ISSN1523-7060
Abstract

Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.

URLhttp://dx.doi.org/10.1021/ol900173t
DOI10.1021/ol900173t
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19275223?dopt=Abstract