Scientific Publications

Skeletally diverse small molecules using a build/couple/pair strategy.

Publication TypeJournal Article
AuthorsUchida, T., Rodriquez M., and Schreiber SL
AbstractIntermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.
Year of Publication2009
JournalOrganic letters
Volume11
Issue7
Pages1559-62
Date Published (YYYY/MM/DD)2009/04/02
ISSN Number1523-7060
DOI10.1021/ol900173t
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19275223?dopt=Abstract