Scientific Publications

Applications of genomics in melanoma oncogene discovery.

Publication TypeJournal Article
AuthorsBerger, MF, and Garraway LA
AbstractThe identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.
Year of Publication2009
JournalHematology/oncology clinics of North America
Volume23
Issue3
Pages397-414, vii
Date Published (YYYY/MM/DD)2009/06/01
ISSN Number0889-8588
DOI10.1016/j.hoc.2009.03.005
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19464593?dopt=Abstract