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Hematol Oncol Clin North Am DOI:10.1016/j.hoc.2009.03.005

Applications of genomics in melanoma oncogene discovery.

Publication TypeJournal Article
Year of Publication2009
AuthorsBerger, MF, Garraway, LA
JournalHematol Oncol Clin North Am
Volume23
Issue3
Pages397-414, vii
Date Published2009 Jun
ISSN1558-1977
KeywordsAnimals, Cell Line, Tumor, Cell Transformation, Neoplastic, DNA, Neoplasm, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Genetic Therapy, Genome, Human, Genomics, Humans, Melanoma, Mice, Neoplasm Proteins, Oligonucleotide Array Sequence Analysis, Oncogenes, Sequence Analysis, DNA
Abstract

The identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0889-8588(09)00041-0
DOI10.1016/j.hoc.2009.03.005
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19464593?dopt=Abstract

Alternate JournalHematol. Oncol. Clin. North Am.
PubMed ID19464593
PubMed Central IDPMC2687404
Grant ListDP2 OD002750 / OD / NIH HHS / United States
DP2 OD002750-01 / OD / NIH HHS / United States
DP2OD002750 / OD / NIH HHS / United States