Applications of genomics in melanoma oncogene discovery.

Hematol Oncol Clin North Am
Authors
Keywords
Abstract

The identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.

Year of Publication
2009
Journal
Hematol Oncol Clin North Am
Volume
23
Issue
3
Pages
397-414, vii
Date Published
2009 Jun
ISSN
1558-1977
URL
DOI
10.1016/j.hoc.2009.03.005
PubMed ID
19464593
PubMed Central ID
PMC2687404
Links
Grant list
DP2 OD002750 / OD / NIH HHS / United States
DP2 OD002750-01 / OD / NIH HHS / United States
DP2OD002750 / OD / NIH HHS / United States