Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at .
Hypertension
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Abstract | The genetic susceptibility to preeclampsia, a pregnancy-specific complication with significant maternal and fetal morbidity, has been poorly characterized. To identify maternal genes associated with preeclampsia risk, we assembled 498 cases and 1864 controls of European ancestry from preeclampsia case-control collections in 5 different US sites (with additional matched population controls), genotyped samples on a cardiovascular gene-centric array composed of variants from ≈2000 genes selected based on prior genetic studies of cardiovascular and metabolic diseases and performed case-control genetic association analysis on 27 429 variants passing quality control. In silico replication testing of 9 lead signals with |
Year of Publication | 2018
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Journal | Hypertension
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Volume | 72
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Issue | 2
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Pages | 408-416
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Date Published | 2018 08
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ISSN | 1524-4563
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DOI | 10.1161/HYPERTENSIONAHA.117.10688
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PubMed ID | 29967039
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PubMed Central ID | PMC6043396
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Links | |
Grant list | K08 HD075831 / HD / NICHD NIH HHS / United States
HHMI / Howard Hughes Medical Institute / United States
R01 HD032579 / HD / NICHD NIH HHS / United States
K12 HD051959 / HD / NICHD NIH HHS / United States
F32 HD086948 / HD / NICHD NIH HHS / United States
R21 HD046624 / HD / NICHD NIH HHS / United States
T32 HL007427 / HL / NHLBI NIH HHS / United States
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