|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Kelly, AR, Wei, J, Kesavan, S, Marié, JC, Windmon, N, Young, DW, Marcaurelle, LA|
A regioselective intramolecular Huisgen cycloaddition was performed on various azido alkyne substrates giving rise to macrocyclic triazole rings. Using catalyst control, a common intermediate has been converted to two structurally unique macrocycles with either a 1,5- or a 1,4-triazole resulting in an n or n + 1 ring size. This is the first example of an intramolecular ruthenium-catalyzed Huisgen cycloaddition.