Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis.
Circ Genom Precis Med
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Abstract | The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk for atherosclerotic cardiovascular disease. Here, we review the prior literature of clonal selection and expansion of hematopoietic stem cells and the evidence supporting its causal association with atherosclerotic cardiovascular disease. |
Year of Publication | 2018
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Journal | Circ Genom Precis Med
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Volume | 11
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Issue | 7
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Pages | e001926
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Date Published | 2018 07
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ISSN | 2574-8300
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DOI | 10.1161/CIRCGEN.118.001926
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PubMed ID | 29987111
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PubMed Central ID | PMC6082163
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Grant list | K08 HL140203 / HL / NHLBI NIH HHS / United States
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